Method

FEIA (Fluorescence Enzyme Immunoassay) – fluorescent enzyme immunoassay, ImmunoCAP (Immunofluorescence on solid phase) – quantitative determination.

Description

Shrimps are small invertebrate marine crustaceans with 10 jointed legs, living on the ocean and lake floors. More than 2000 species of shrimp are known. The main allergenic component is tropomyosin (Pen a1) – a heat-stable protein that makes up to 20% of the total protein in the edible part of the animal. Recombinant Pen a1 and natural Pen a1 are structurally and immunologically identical, ensuring high accuracy in diagnosing shrimp allergy.

Indications

Diagnosis of allergic reactions to shrimp.
Assessment of sensitization level and risk of allergy development.
Monitoring the effectiveness of therapy.
Assessment of sensitization level after allergen avoidance.
Evaluation of immune system status.

Preparation

Blood should be drawn in the morning on an empty stomach or 4 hours after eating.
Drinking plain still water is allowed.
Do not smoke for 30 minutes before the test.
For children under 1 year – do not feed 30-40 minutes before the test; for children 1-5 years – 2-3 hours fasting.

Clinical Significance

rPen a1 is the main allergenic component of brown shrimp (P. aztecus) and a representative of tropomyosin from other shrimp species. Tropomyosin is a pan-allergen with high cross-reactivity among invertebrates. Detection of IgE antibodies to Pen a1 allows accurate diagnosis of crustacean allergy, therapy monitoring, and development of personalized treatment plans. Recombinant allergens are an important tool in molecular allergology, providing high specificity and sensitivity of the test.

rPen a1 Shrimp, tropomyosin (f351)1435

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