Method

FEIA (Fluorescence Enzyme Immunoassay), ImmunoCAP (Solid-phase Immunofluorescence) – quantitative determination of the allergen component.

Description

Gad c1 – the main allergen component of Baltic cod (Gadus callarias), belonging to the beta-line of the parvalbumin family. This heat-stable allergen is present in the light muscles of the fish and plays an important role in calcium homeostasis during muscle relaxation. Gad c1 causes allergic reactions when consuming fish or inhaling the allergen during fish processing. It has cross-reactivity with other species of bony fish.

Indications

Diagnosis of allergic reactions to fish.
Assessment of sensitization level and risk of allergy development.
Monitoring the effectiveness of ongoing therapy.
Evaluation of sensitization level after allergen avoidance.
Assessment of immune system status.

Preparation

Blood should be drawn in the morning on an empty stomach or 4 hours after eating.
Drinking plain still water is allowed.
Do not smoke for 30 minutes before the test.
For children under 1 year – do not feed 30-40 minutes before the test; for children 1-5 years – 2-3 hours fasting.

Clinical Significance

Gad c1 is a cytosolic protein found in the light muscles of bony fish but absent in fish gelatin and eggs. Sensitization to fish parvalbumin can cause symptoms ranging from mild to severe, including anaphylaxis. There are various models of IgE-mediated fish allergy reflecting the degree of cross-reactivity. Cross-reactivity extends not only to fish but also to other species, including frogs, chickens, and crocodiles.

rGad c1 Chip (f426)1608

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