Method

FEIA (Fluorescence Enzyme Immunoassay) – a fluorescent enzyme immunoassay that provides quantitative determination of the allergen component level.

Description

rFel d1 is an allergen component of the domestic cat epithelium (Felis domesticus). It is a uterokinin-like protein found in fur, dander, saliva, tear fluid, and secretions of the cat's anal glands, but absent in urine and serum. Protein secretion depends on hormonal status and testosterone levels: males have more than females, and secretion decreases after castration. Regardless of breed, color, or fur length, this protein is released into the environment in large quantities.

Indications

Diagnosis of allergic reactions to the cat allergen component.
Assessment of sensitization level and risk of developing allergic reactions.
Monitoring the effectiveness of ongoing therapy.
Assessment of sensitization level after allergen avoidance.
Evaluation of immune system status.

Preparation

Blood should be drawn in the morning on an empty stomach or 4 hours after eating.
Drinking plain still water is allowed.
Do not smoke for 30 minutes before the test.
For children under 1 year – no food 30-40 minutes before the test; for children 1-5 years – 2-3 hours fasting.

Clinical Significance

Elevated Fel d1 IgE levels are an important risk factor for developing allergic asthma in children. Studies have shown a strong link between Fel d1 and the prevalence, severity, and persistence of asthma. Patients sensitized to the cat allergen component have a higher likelihood of developing asthma and rhinitis. Research among patients allergic to cats revealed that over 94% of adults and children had IgE against Fel d1, and IgE levels in children with asthma were significantly higher than in children with rhinoconjunctivitis.

rFel d1 Cat, Felis domesticus (e94)1336

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