Method

FEIA (Fluorescence Enzyme Immunoassay), ImmunoCAP (Solid-phase Immunofluorescence) – quantitative determination.

Description

rDer p1 – allergen component of the house dust mite Dermatophagoides pteronyssinus, one of the most active house dust allergens. This mite lives in beds and bedding, feeding on skin flakes. It is found on the skin, in urine, sputum, and lungs of patients and causes allergic reactions related to sensitization to mites and their metabolites.

Indications

Diagnosis of allergic reactions.
Assessment of sensitization level and risk of allergy development.
Monitoring therapy effectiveness.
Assessment of sensitization level after allergen avoidance.
Evaluation of immune system status.

Preparation

Blood should be drawn in the morning on an empty stomach or 4 hours after eating.
Drinking plain still water is allowed.
Do not smoke for 30 minutes before the test.
For children under 1 year – no food 30-40 minutes before the test; for children 1-5 years – 2-3 hours fasting.

Clinical Significance

Der p1 is one of the main allergen components of house dust mites with a sensitization prevalence of 70-100%. Inhalation of mite feces increases asthma risk up to fivefold. Reducing exposure to Der p1 decreases symptoms of rhinitis and asthma. A high degree of cross-reactivity with Der f1 (Dermatophagoides farinae) is important for selecting specific immunotherapy (SIT). Biochemically, Der p1 is a glycoprotein with a molecular weight of 25 kDa that disrupts the epithelial barrier and stimulates inflammatory processes in the airways.

rDer p1 House Dust Mite Dermatophagoides pteronyssinus (d202)1316

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