rCor a8 Hazelnut, LTP (f425)1570
Cor a8 – nonspecific lipid transfer protein (nsLTP), panallergen of hazelnuts (Corylus avellana). It is a PR-14 protein with a molecular weight of 9 kDa, characterized by high thermal stability and resistance to gastrointestinal digestion. Sensitization to Cor a8 is more common in regions without endemic birch, such as the Mediterranean, and can be associated with both severe allergic reactions and mild symptoms like oral allergy syndrome to hazelnut. Cor a8 is often associated with other nsLTPs, particularly Pru p3 (peach) and Jug r3 (walnut), and may show cross-reactivity with them.
FEIA (Fluorescence Enzyme Immunoassay) – fluorescent enzyme immunoassay, ImmunoCAP (Solid-phase Immunofluorescence) – quantitative determination.
- Diagnosis of allergic reactions to hazelnut.
- Assessment of sensitization level and risk of allergic reactions.
- Monitoring the effectiveness of ongoing therapy.
- Evaluation of sensitization level after allergen avoidance.
- Assessment of immune system status.
- Blood should be drawn in the morning on an empty stomach or 4 hours after eating.
- Drinking plain still water is allowed.
- Do not smoke for 30 minutes before the test.
- For children under 1 year – no food 30-40 minutes before the test; for children 1-5 years – 2-3 hours fasting.
Hazelnut allergy is one of the most common nut allergies in Europe, accounting for 17% to 100% of nut allergy cases. Cor a8 is a key allergen component that can cause both severe and mild allergic reactions. Sensitization to Cor a8 is also common outside Europe, including India, Israel, Australia, Mexico, and South Africa. This protein exhibits cross-reactivity with other nsLTPs, which is important to consider in allergy diagnosis and treatment.