Method

FEIA (Fluorescence Enzyme Immunoassay) – quantitative determination of specific antibodies.

Description

Amoxicillin — a semi-synthetic broad-spectrum antibiotic of the penicillin group. The test allows detection of sensitization to amoxicillin and assessment of the body's immune responses to this drug.

Indications

Diagnosis of allergic diseases associated with sensitization to amoxicillin.
Differential diagnosis of complex cases with atypical manifestations and/or course when amoxicillin intolerance is suspected.
Assessment of the prognosis for tolerance development at various stages of the treatment process.

Preparation

Blood should be drawn in the morning on an empty stomach or 4 hours after eating.
Drinking plain still water is allowed.
Do not smoke for 30 minutes before the test.
Children under 1 year should not eat for 30-40 minutes before the test; for children aged 1-5 years, 2-3 hours fasting is recommended.

Clinical Significance

The immune mechanisms underlying drug allergy distinguish it from toxic-allergic and pseudoallergic reactions. According to the classification by P. Gell and R. Coombs, immune reactions are divided into 4 types: immediate (Type I), cytotoxic (Type II), immune complex (Type III), and delayed hypersensitivity (Type IV). Most cases of drug allergy (77%) are associated with Type I reactions, 5% with Type III, and 9% with Type IV. The course of drug allergy may involve several mechanisms simultaneously.

Determination of specific IgG antibodies is important for Type II and Type III reactions, which are accompanied by cytotoxicity and immune complex tissue damage respectively, clinically manifesting as various allergic and autoimmune conditions, including hemolytic anemia, agranulocytosis, serum sickness, vasculitis, and others.

Amoxicillin, IgG (c204)2008

Specifications

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