Method

PHOT (photometry) – quantitative determination of aldolase enzyme activity in blood serum.

Description

Aldolase is an enzyme that plays a key role in carbohydrate metabolism, particularly in the glycolysis process. It catalyzes the cleavage of fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, which are important steps in energy (ATP) production within cells. Elevated aldolase levels may indicate muscle tissue or liver damage, as well as inflammatory processes.

Indications

Progressive Duchenne muscular dystrophy
Dermatomyositis
Polymyositis
Trichinosis
Myopathies
Monitoring patients with muscular dystrophy
Differential diagnosis with neurological diseases (poliomyelitis, myasthenia, multiple sclerosis)

Preparation

Blood sampling is performed in the morning on an empty stomach or 4 hours after the last meal. Drinking plain still water is allowed. Do not smoke for 30 minutes before the test. For children under 1 year – do not feed 30-40 minutes before the test; for children aged 1-5 years – 2-3 hours fasting. Avoid physical and emotional stress for 30 minutes before blood collection.

Clinical significance

Determining aldolase activity is important for diagnosing and monitoring muscle and liver diseases. Increased activity is observed in muscular dystrophies, inflammatory myopathies, viral hepatitis, myocardial infarction, and other pathologies. Test results help assess the extent of tissue damage and the effectiveness of treatment.

Aldolase – biochemical blood test0165

Specifications

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