This test determines sensitization to a mixture of fruits associated with birch pollen. The analysis allows assessment of the level of allergic reaction and the risk of developing an allergy to these fruits. The detection takes into account the influence of allergenic proteins such as Mal d1, Pru p3, Pyr c3, and others, which cause cross-reactions between birch pollen and fruits of the Rosaceae family. The test helps diagnose both true food allergies and cross-sensitizations arising from component similarities.
All fruits of the Rosaceae family can cause both primary and cross-allergy depending on the region and type of sensitization. Allergy to green apple is linked to the Mal d1 protein, whose concentration increases with prolonged fruit storage. In pear, the main allergenic component is Pyr c3 (LTP), related to peach Pru p3, often causing cross-reactions even after heat treatment. In cherry and sweet cherry, several proteins (Pru av1, av2, av3) are active and can cause both oral allergy syndrome and food sensitization, even to processed fruits. Plum contains the Pru d1 protein, related to birch Bet v1, causing the "birch-fruit" syndrome with typical symptoms in the oral cavity.
In Northern and Central Europe, the birch-fruit syndrome is common, where cross-allergy arises due to the similarity of birch pollen and fruit allergens. Detecting sensitization helps in choosing the correct treatment and prevention of allergic reactions.
FEIA (Fluorescence Enzyme Immunoassay, ImmunoCAP (Solid-phase Immunofluorescence)) – quantitative determination.
Please note that the research method and reference values may vary depending on the equipment and test systems used.