Study of Creatine Kinase Isoenzymes (CK-MM, CK-MB, CK-BB, Macro-CK)0483
The study of creatine kinase isoenzymes (CK-MM, CK-MB, CK-BB, Macro-CK) allows for the determination of the activity of different enzyme forms, aiding in the diagnosis of myocardial damage, muscle system disorders, and other pathologies. Creatine kinase is a key enzyme in cellular energy metabolism, and its isoenzymes have specific distribution in body tissues.
Creatine kinase has two subunits – M (muscle) and B (brain). Their combinations form isoenzymes that reflect damage to different tissues:
- MM fraction – indicates damage to skeletal muscles and, to a lesser extent, the heart.
- MB fraction – specific to the myocardium, used for diagnosing myocardial infarction.
- BB fraction – associated with oncological diseases, myeloproliferative syndromes, and neurological disorders.
- Macro-CK type I – standard variant without clinical significance.
- Macro-CK type II – found in severe diseases and tumors.
Determining creatine kinase isoenzymes helps differentiate tissue damage and assess the degree of pathology.
- Clarification of unexplained elevated CK-MB activity.
- Detection of macro-CK.
- Differentiation of elevated creatine kinase.
- Diagnosis and monitoring of myocardial infarction.
- Assessment of muscle system diseases.
ELPHO (Electrophoresis) – quantitative determination of creatine kinase isoenzymes.
Please note that the research method and reference values may vary depending on the equipment and test systems used.
Blood sampling is performed in the morning on an empty stomach or 12 hours after the last meal. Drinking plain still water is allowed. Do not smoke for 30 minutes before the test. For children under 1 year – no food 30-40 minutes before the test; for children 1-5 years – 2-3 hours fasting. It is important to avoid physical and emotional stress for 30 minutes before the test. With doctor's approval, discontinue medications 12 hours before the test.