Sardines (Sardina pilchardus, Sardinops sagax, and related species) belong to the herring family, inhabiting the Atlantic, Pacific, and Mediterranean seas. This fish is a food, contact, and inhalation allergen. The main allergenic component is parvalbumin proteins in the muscle tissue. Fish allergy is more common in children and can cause various symptoms – skin, gastrointestinal, cardiovascular, respiratory, as well as anaphylaxis. There is cross-reactivity between different species of bony fish, but it is not always clinically significant.
Allergens of the Clupeidae family include Sar p1, Sar m1, Sar sa1 – the main allergenic molecules of sardines. There is high structural homology (62–74%) between ß-parvalbumin isoforms of various bony fish species, causing cross-reactivity. However, the clinical significance of this cross-reactivity may be limited to certain species. Additional allergenic components include enolases, aldolases, and fish gelatin, which can also trigger allergic reactions.
FEIA (Fluorescence Enzyme Immunoassay, ImmunoCAP) – quantitative determination of specific IgE to sardine allergen.
Please note that the research method and reference values may vary depending on the equipment and test systems used.