rGly m4 Soy, PR-10 (f353)1345
Gly m4 is the main soy allergen component for patients with birch pollen allergy, explaining the cross-reaction to soy in adults. It is a panallergen from the PR-10 group with a molecular weight of 17 kDa. The concentration of Gly m4 varies in different soy products depending on soy content, processing, and heating. Sensitization to Gly m4 can cause oral allergy syndrome, gastrointestinal, respiratory symptoms, and anaphylaxis after soy consumption. Gly m4 cross-reacts with allergens from other legumes and pollen allergen components such as Bet v1, Aln g1, Ara h8, Cor a1.01, Mal d1, and others.
FEIA (Fluorescence Enzyme Immunoassay), ImmunoCAP (Solid-phase Immunofluorescence) – quantitative determination.
- Diagnosis of allergic reactions to soy.
- Assessment of sensitization level and risk of allergy development.
- Monitoring therapy effectiveness.
- Evaluation of sensitization level after allergen avoidance.
- Assessment of immune system status.
- Blood should be drawn in the morning on an empty stomach or 4 hours after eating.
- Drinking plain still water is allowed.
- Do not smoke for 30 minutes before the test.
- For children under 1 year – no food 30-40 minutes before the test; for children 1-5 years – 2-3 hours fasting.
Soybeans are part of the "big eight" food allergens causing 90% of food allergies. Gly m4 is a homolog of Bet v1 and is responsible for soy allergy associated with birch pollen, especially in regions with high birch sensitization rates. This allergen component is an important marker for diagnosing severe allergic reactions to soy, oral allergy syndrome, and systemic reactions. Cross-reactivity between Gly m4 and peanut and other legume allergens is also noted.