Gad c1 – the main allergen component of Baltic cod (Gadus callarias), belonging to the beta-line of the parvalbumin family. This heat-stable allergen is present in the light muscles of the fish and plays an important role in calcium homeostasis during muscle relaxation. Gad c1 causes allergic reactions when consuming fish or inhaling the allergen during fish processing. It has cross-reactivity with other species of bony fish.
Gad c1 is a cytosolic protein found in the light muscles of bony fish but absent in fish gelatin and eggs. Sensitization to fish parvalbumin can cause symptoms ranging from mild to severe, including anaphylaxis. There are various models of IgE-mediated fish allergy reflecting the degree of cross-reactivity. Cross-reactivity extends not only to fish but also to other species, including frogs, chickens, and crocodiles.
FEIA (Fluorescence Enzyme Immunoassay), ImmunoCAP (Solid-phase Immunofluorescence) – quantitative determination of the allergen component.
Please note that the research method and reference values may vary depending on the equipment and test systems used.