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Ara h1 — a storage protein of vicilin seed, a member of the 7S globulin family, capable of resisting gastrointestinal conditions. It constitutes about 20% of peanut protein. 97% of patients with peanut allergy are sensitized to Ara h1, h2, or h3. Sensitization to Ara h1 is associated with an increased risk of severe allergic reactions, including anaphylaxis. Roasting peanuts increases the allergenicity of Ara h1. Immunological testing of specific IgE to Ara h1, h2, and h3 helps diagnose allergy and assess the severity of the reaction. Cross-reactions with other legumes and nuts are known.
Peanut allergy affects 1-2% of the population in Western countries, usually beginning in childhood and often persisting throughout life. Sensitization to Ara h1 is associated with more severe symptoms, including anaphylactic reactions. Patients with a positive test have an increased risk of systemic inflammation and respiratory symptoms. Cross-reactions with other nuts, legumes, and their proteins complicate diagnosis and treatment. Detection of Ara h1 helps predict allergy severity and tailor individual therapy.
FEIA (Fluorescence Enzyme Immunoassay), ImmunoCAP (Solid-phase Immunofluorescence) – quantitative determination.
Please note that the research method and reference values may vary depending on the equipment and test systems used.