Protamine (protamine sulfate) is a coagulant, hemostatic agent, and heparin antidote. It exhibits a specific anti-hemorrhagic effect in bleeding caused by heparin overdose. The test determines the level of sensitization to protamine, aiding in the diagnosis of allergic reactions.
Adverse reactions to protamine sulfate can cause type I anaphylactic reactions, including arterial hypotension, bronchospasm, as well as skin and mucous membrane manifestations. The severity of reactions ranges from mild to life-threatening. Risk factors include insulin-dependent diabetes mellitus, vasectomy, fish allergy, prior exposure to protamine, and infusion rate.
FEIA (Fluorescence Enzyme Immunoassay) using ImmunoCAP (Solid-phase Immunofluorescence) – quantitative determination.
Please note that the research method and reference values may vary depending on the equipment and test systems used.