Protamine (c207)1445
Protamine (protamine sulfate) is a coagulant, hemostatic agent, and heparin antidote. It exhibits a specific anti-hemorrhagic effect in bleeding caused by heparin overdose. The test determines the level of sensitization to protamine, aiding in the diagnosis of allergic reactions.
FEIA (Fluorescence Enzyme Immunoassay) using ImmunoCAP (Solid-phase Immunofluorescence) – quantitative determination.
- Diagnosis of allergic reactions to protamine.
- Assessment of sensitization level and risk of allergic reactions.
- Monitoring the effectiveness of therapy.
- Evaluation of sensitization level after allergen avoidance.
- Assessment of immune system status.
- Draw blood in the morning on an empty stomach or 4 hours after eating.
- Drinking plain still water is allowed.
- Do not smoke for 30 minutes before the test.
- For children under 1 year – no food 30-40 minutes before the test; for children 1-5 years – 2-3 hours fasting.
Adverse reactions to protamine sulfate can cause type I anaphylactic reactions, including arterial hypotension, bronchospasm, as well as skin and mucous membrane manifestations. The severity of reactions ranges from mild to life-threatening. Risk factors include insulin-dependent diabetes mellitus, vasectomy, fish allergy, prior exposure to protamine, and infusion rate.