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Penicillin G (c1)1216

1150.001092.00 ₴
Available

Penicillin G (benzylpenicillin) is a naturally derived antibiotic produced by industrial fermentation of Penicillium chrysogenum. Small penicillin molecules alone do not induce an immune response; however, the beta-lactam ring of penicillin forms covalent bonds with proteins, creating hapten-protein conjugates. These conjugates trigger allergic reactions, and Penicilloyl G (c1) is the major allergenic determinant of penicillin G with potential cross-reactivity with other penicillins.

Penicillin allergy can manifest as immediate reactions (urticaria, angioedema, bronchospasm, anaphylaxis) and delayed reactions (maculopapular rash, delayed urticaria). Immediate reactions are associated with IgE-mediated mechanisms, while delayed reactions involve T-cell sensitization. The Penicilloyl G (c1) IgE test has high clinical specificity but limited sensitivity, so a negative result does not exclude penicillin allergy. Additional skin tests are recommended for comprehensive diagnosis.

  • Diagnosis of allergic reactions to penicillin.
  • Assessment of sensitization level and risk of allergy development.
  • Monitoring therapy effectiveness.
  • Evaluation of decreased sensitization after allergen avoidance.
  • Assessment of immune system status.

FEIA (Fluorescence Enzyme Immunoassay) – quantitative determination of specific IgE antibodies to penicillin.

Please note that the research method and reference values may vary depending on the equipment and test systems used.

  • Blood should be drawn in the morning on an empty stomach or 4 hours after eating.
  • Drinking plain still water is allowed.
  • Do not smoke 30 minutes before the test.
  • For children under 1 year – no food 30-40 minutes before the test; for children 1-5 years – 2-3 hours fasting.

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