Penicillin G (c1)1216
Penicillin G (benzylpenicillin) is a naturally derived antibiotic produced by industrial fermentation of Penicillium chrysogenum. Small penicillin molecules alone do not induce an immune response; however, the beta-lactam ring of penicillin forms covalent bonds with proteins, creating hapten-protein conjugates. These conjugates trigger allergic reactions, and Penicilloyl G (c1) is the major allergenic determinant of penicillin G with potential cross-reactivity with other penicillins.
FEIA (Fluorescence Enzyme Immunoassay) – quantitative determination of specific IgE antibodies to penicillin.
- Diagnosis of allergic reactions to penicillin.
- Assessment of sensitization level and risk of allergy development.
- Monitoring therapy effectiveness.
- Evaluation of decreased sensitization after allergen avoidance.
- Assessment of immune system status.
- Blood should be drawn in the morning on an empty stomach or 4 hours after eating.
- Drinking plain still water is allowed.
- Do not smoke 30 minutes before the test.
- For children under 1 year – no food 30-40 minutes before the test; for children 1-5 years – 2-3 hours fasting.
Penicillin allergy can manifest as immediate reactions (urticaria, angioedema, bronchospasm, anaphylaxis) and delayed reactions (maculopapular rash, delayed urticaria). Immediate reactions are associated with IgE-mediated mechanisms, while delayed reactions involve T-cell sensitization. The Penicilloyl G (c1) IgE test has high clinical specificity but limited sensitivity, so a negative result does not exclude penicillin allergy. Additional skin tests are recommended for comprehensive diagnosis.