Package "Autoimmune Bullous Dermatoses (Tissue Immunoglobulins, IF)"2028
The study aims to detect autoantibodies that serve as biomarkers for autoimmune bullous dermatoses. Particularly important is the detection of antibodies against fibrillarin, which is a relatively specific marker for scleroderma (SSc).
Direct immunofluorescence (IF) is a method for detecting tissue immunoglobulins (IgG, IgA, IgM), complement C3, and fibrillarin protein in skin fragments.
- Bullous pemphigoid
- Pemphigus (blister)
- Linear IgA dermatitis
- Acquired bullous epidermolysis
- Dermatitis herpetiformis
For the analysis, a skin fragment should be taken from an erythematous (healthy) area or around a fresh blister. A biopsy from the oral cavity is taken from mucosa without pathological changes. The accompanying referral must specify the biopsy site, suspected diagnosis, and list of required tests.
Bullous pemphigoid is a chronic autoimmune skin disease that leads to itchy, blistering lesions, mainly in elderly patients. Diagnosis is established through biopsy and immunofluorescence. Treatment includes topical and systemic corticosteroids, as well as immunosuppressants for maintenance therapy. The first symptom is itching, and characteristic bullae may appear on the trunk skin and flexural areas. Mucous membrane involvement is rare. Nikolsky's sign is usually negative.