The European hornet (Vespa crabro) is a large wasp native to Europe and Asia. It uses venom for self-defense and prey capture through its stinging apparatus. V. crabro venom contains three main allergenic molecules that can cause severe allergic reactions, including anaphylaxis. These allergens partially cross-react with venom proteins of other hymenopteran insects, such as yellow jackets (Vespula spp.) and the honeybee (Apis mellifera).
Antigen 5 (Vesp c5) is the most allergenic component of hornet venom, which has no toxic effect but serves as a key biomarker for the severity of allergic reactions. There is significant cross-reactivity between allergens of different hymenopteran species due to structural and antigenic similarity of Vesp c1, Vesp c2, and Vesp c5 proteins with proteins of other wasps, particularly yellow jackets. This is important for accurate diagnosis and development of therapeutic strategies.
FEIA (Fluorescence Enzyme Immunoassay), ImmunoCAP (Solid-phase Immunofluorescence) – quantitative determination.
Please note that the research method and reference values may vary depending on the equipment and test systems used.