Histamine in urine

Mast cells are located throughout the body: in the skin, intestinal mucosa, respiratory tract, and bone marrow. They contain granules with histamine and tryptase, which are released upon cell activation, causing allergic symptoms. Elevated histamine levels in urine indicate severe allergic reactions, mastocytosis, and other conditions associated with abnormal increase or activation of mast cells. The test helps timely diagnosis and monitoring of these conditions, as well as assessing the risk of anaphylactic reactions.

• Diagnosis of tumors: mastocytoma, polycythemia vera, chronic myeloid leukemia, carcinoids.
• Diagnosis of interstitial cystitis.
• Assessment of allergic reactivity and nonspecific inflammation.
• Detection of mastocytosis and other disorders related to mast cell activation.

RIA (Radio-Immunoassay) – quantitative determination.

• Collect 10 ml of spontaneous urine, preferably the midstream portion of the first morning urine. The first few milliliters should be voided into the toilet.
• Use a labeled disposable plastic container without preservative for collection.
• Avoid alcohol, nicotine, coffee, tea, cocoa, and foods high in histamine (wine, cheese, sauerkraut, avocado, bananas, canned products) for 48 hours before urine collection.
• Avoid medications that may affect results (sympathomimetics) for 2 weeks before testing, after consulting with a physician.
• Avoid physical and emotional stress 24 hours before the test.
• Women are advised to collect urine before menstruation begins or 2-3 days after it ends.
• Perform thorough hygiene of external genitalia before collection.
• For children, collect urine using a urine collection bag after thorough hygiene. Urine from diapers is not suitable for testing.