Method

IFT (Immunofluorescence test) – immunofluorescence test.

Description

Determination of EMA IgA is one of the key tests in the diagnosis of celiac disease and dermatitis herpetiformis. Tissue transglutaminase acts as the main antigen for endomysial antibodies in celiac disease. Antigens for endomysial antibodies are present in various body tissues such as the esophagus, umbilical cord, stomach, liver, which are used as antigenic substrates in fluorescent immunological analysis.

Indications

Suspected celiac disease (over 90% of untreated patients have a positive test).
Intermittent diarrhea alternating with constipation.
Weight loss.
Growth retardation in children or abdominal bloating.
Osteoporosis.
Iron deficiency anemia.
Folic acid deficiency with tooth enamel damage.
Monitoring patients on a gluten-free diet.
Suspected dermatitis herpetiformis (positive in 90% of cases).

Preparation

Blood collection in the morning on an empty stomach or 4 hours after eating. Drinking plain still water is allowed. Do not smoke 30 minutes before the test. For children under 1 year – no food 30-40 minutes before the test; for children 1-5 years – 2-3 hours fasting.

Clinical significance

Celiac disease is an autoimmune disorder of the small intestine with a genetic predisposition, characterized by villous atrophy of the mucous membrane and malabsorption syndrome. Genetic factors HLA-DQ2 and HLA-DQ8 increase the risk of developing celiac disease due to strong binding with gliadin, leading to villous atrophy, impaired nutrient absorption, and typical symptoms: chronic diarrhea, abdominal bloating, weight loss, growth delay. The disease is most often detected in children from 6 months to 2 years or in adults aged 20-40 years. Women are affected 2-3 times more often than men.

Endomysium – AT (IgA) / AK g. Endomysium2864

Specifications

Viewed tests

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