Method

FEIA (Fluorescence Enzyme Immunoassay) – quantitative determination.

Description

Acetylsalicylic acid (aspirin) is a nonsteroidal anti-inflammatory drug (NSAID), a derivative of salicylic acid, with anti-aggregation, antipyretic, analgesic, and anti-inflammatory effects.

Indications

Diagnosis of allergic reactions to acetylsalicylic acid.
Assessment of sensitization level and risk of allergic reactions.
Monitoring the effectiveness of ongoing therapy.
Evaluation of sensitization level after allergen avoidance.
Assessment of immune system status.

Preparation

Have blood drawn in the morning on an empty stomach or 4 hours after eating.
Drinking plain still water is allowed.
Do not smoke for 30 minutes before the test.
Children under 1 year should not eat for 30-40 minutes before the test; for children aged 1-5 years, fasting for 2-3 hours is recommended.

Clinical Significance

Hypersensitivity to aspirin and other NSAIDs may manifest as hives, itching, swelling, shortness of breath, nasal congestion, wheezing, weakness, or even loss of consciousness. There is a risk of anaphylactic shock—a life-threatening condition.

Most patients with aspirin hypersensitivity react similarly to other NSAIDs and may also have allergy-like reactions to paracetamol (acetaminophen). In some cases, allergic reactions occur only to specific NSAIDs.

In patients with bronchial asthma, nasal polyps, or chronic sinusitis, aspirin and NSAID intake can cause shortness of breath, wheezing, and nasal congestion—this condition is known as aspirin-exacerbated respiratory disease.

In patients with chronic urticaria, 20% to 40% may experience worsening symptoms after taking aspirin or NSAIDs, including symptom intensification and development of angioedema (Quincke's edema).

Acetylsalicylic Acid (Aspirin) (s51)2207

Specifications

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